|
T10515 |
Anti-Heart Failure Agent 1
|
|
Others
|
|
Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness. |
|
T2320 |
Indacaterol
|
|
Adrenergic Receptor
|
|
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist. |
|
T5033 |
Olprinone
|
Loprinone |
PDE
|
|
Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ... |
|
T9022 |
AZD9977
|
AZD 9977 |
Glucocorticoid Receptor
|
|
AZD9977 is a novel, selective modulator of mineralocorticoid receptor . |
|
T16873 |
SERCA2a activator 1
|
|
Calcium Channel
|
|
SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart. |
|
T7686 |
Ramiprilat
|
|
RAAS
|
|
Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
|
T14989 |
CMPD101
|
|
ROCK
,
GRK
,
PKC
|
|
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I... |
|
T39789 |
BMS-986235
|
BMS-986235,LAR-1219 |
Others
|
|
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the preventio... |
|
T6716 |
Valsartan
|
Diovan,Tareg,CGP 48933 |
RAAS
|
|
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension. |
|
T5329 |
Trandolapril
|
|
Angiotensin-converting Enzyme (ACE)
|
|
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. |
|
T1461 |
Candesartan
|
CV 11974 |
RAAS
|
|
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. |
|
T4574 |
Sacubitril
|
AHU 377,AHU377,AHU-377 |
Neprilysin
|
|
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. |
|
T1410 |
Torsemide
|
AC-4464,JDL-464,Torasemide |
Na-K-Cl cotransporter
|
|
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h... |
|
T7714 |
Temocapil
|
|
Tyrosinase
|
|
Temocapril is an inhibitor of tyrosine kinase. |
|
T3465 |
Vesnarinone
|
OPC-8212,Arkin,Piteranometozine |
HIV Protease
,
PDE
|
|
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel... |
|
T1239 |
Indacaterol maleate
|
QAB149 |
Adrenergic Receptor
|
|
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. |
|
T24850 |
Takeda103A
|
CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A |
GRK
|
|
Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor. |
|
T0154 |
Nebivolol hydrochloride
|
R 065824 hydrochloride,Nebivolol HCl,R-65824 |
Apoptosis
,
Adrenergic Receptor
|
|
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us... |
|
T1275 |
Phentolamine mesylate
|
Phentolamine methanesulfonate,Phentolamine mesilate |
Adrenergic Receptor
|
|
Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS... |
|
T0083 |
Eplerenone
|
Epoxymexrenone,CGP 30083,SC-66110 |
Glucocorticoid Receptor
|
|
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... |
|
T6551 |
Isosorbide
|
Devicoran,Isobide,Hydronol,Dianhydro-D-glucitol,D-Isosorbide |
Others
|
|
Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic. |
|
T8867 |
RO2959 Hydrochloride
|
RO2959 HCl |
IL Receptor
,
Calcium Channel
,
Interleukin
|
|
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
|
T1462 |
Captopril
|
SQ 14225,SQ-14534,SA333 |
RAAS
|
|
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. |
|
T6542 |
Imidapril hydrochloride
|
Novaloc,Imidapril HCl,Tanapril,TA-6366 |
RAAS
|
|
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. |
|
T1615 |
Irbesartan
|
SR-47436,BMS-186295 |
Apoptosis
,
RAAS
|
|
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. |
|
T6991 |
Nitroprusside disodium dihydrate
|
Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate |
Guanylate cyclase
,
Autophagy
|
|
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood. |
|
T0342 |
Carvedilol phosphate hemihydrate
|
Carvedilol phosphate,BM 14190 (phosphate hemihydrate) |
VEGFR
,
Others
,
Potassium Channel
,
LDL
,
Integrin
,
Gap Junction Protein
,
NADPH
,
Adrenergic Receptor
,
Autophagy
|
|
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom... |
|
T6698 |
Temocapril hydrochloride
|
CS-622 HCl,Acecol,Temocapril HCl,CS-622 |
RAAS
|
|
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. |
|
T0143 |
Bisoprolol hemifumarate
|
(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate) |
Adrenergic Receptor
|
|
Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby with antihypertensive activity and devoid of intrinsic sy... |
|
T2006 |
Omecamtiv mecarbil
|
CK-1827452 |
ATPase
,
Myosin
|
|
Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among othe... |
|
T33600L |
(Rac)-Naxifylline
|
(Rac)-Naxifylline（(Rac)-166374-49-8） |
Others
|
|
(Rac)-Naxifylline may be used to study congestive heart failure. |
|
T31605 |
Edonentan
|
BMS207940,BMS-207940,BMS 207940 |
Endothelin Receptor
|
|
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure. |
|
T31805 |
Flosequinan
|
|
Others
|
|
Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure. |
|
T68036 |
Carprazidil
|
|
Others
|
|
Carprazidil is a potent vasodilator used to treat severe hypertension and mild heart failure. |
|
T28437L |
Pomisartan 2HCl
|
Pomisartan 2HCl(144702-17-0 Free base),BIBR363 2HCL |
RAAS
|
|
Pomisartan 2HCl (BIBR363 2HCL) is a small molecule AT1R antagonist used to study heart failure and hypertension. |
|
T27596 |
Imazodan hydrochloride
|
CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl |
PDE
|
|
Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure. |
|
T12315 |
OR-1896
|
|
PDE
|
|
OR-1896 is the active metabolite of Levosimendan, a highly specific phosphodiesterase (PDE III) inhibitor, a vasodilator with partial anti-inflammatory properties that produces vasodilation in different types of blood ve... |
|
T10631 |
Bucindolol
|
BMY 13105,MJ 131051,MJ 13105 |
Adrenergic Receptor
|
|
Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure. |
|
T10631L |
Bucindolol Formate
|
Bucindolol Formate (71119-11-4 Free base) |
Adrenergic Receptor
|
|
Bucindolol Formatel is a blocker of β1-adrenergic receptor. Bucindolol exhibits intrinsic sympathomimetic activity. Bucindolol can be used in the research of heart failure. |
|
T6486 |
Enalapril Maleate
|
MK-421 Maleate,Renitec Maleate,Glioten Maleate,MK-421 (maleate),Vasotec Maleate |
RAAS
|
|
Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy. |
|
T28437 |
Pomisartan
|
BIBR-363,BIBR 363,BIBR363 |
RAAS
|
|
Pomisartan (BIBR-363) is a small molecule angiotensin type 1 receptor (AT1R) antagonist that is used in the treatment of cardiovascular disease, studying heart failure and hypertensio |
|
T63838 |
AZD5462
|
|
RXFP receptor
|
|
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer. |
|
T67941 |
PDE5-IN-9
|
|
|
|
PDE5-IN-9 inhibits Phosphodiesterase PDE1c and is used to treat hypertension, heart failure, myocardial infarction, kidney failure, asthma, bronchitis, and dementia. |
|
T33711L |
Nolomirole HCl
|
CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride |
Dopamine Receptor
,
Norepinephrine
|
|
Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study mild chronic heart failure. |
|
T39448 |
BMS-986224
|
BMS 986224 |
Apelin receptor
|
|
BMS-986224 is an orally active, potent, and selective APJ receptor agonist. BMS-986224 has the potential to study heart failure. |
|
T61913 |
Cavutilide
|
|
EGFR
|
|
Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation. |
|
T6595 |
Moexipril hydrochloride
|
Moexipril HCl,RS-10085,SPM 925,CI-925 |
Apoptosis
,
RAAS
|
|
Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure. |
|
T1182 |
Levocarnitine propionate hydrochloride
|
Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,ST-261 |
Histamine Receptor
|
|
Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases. |
|
T28124 |
N106
|
N-106,N 106 |
E1/E2/E3 Enzyme
|
|
N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure. |
|
T71744 |
Imazodan
|
|
PDE
|
|
Imazodan, a small molecule compound with positive inotropic activity, is a selective type III phosphodiesterase inhibitor and can be used to study heart failure. |
